アンドロゲン依存性症状

アンドロゲン依存性症状(Androgen-dependent condition, disease, disorder, or syndrome)は、体内のアンドロゲン活性の存在に一部または全部が依存している、あるいは過敏である医学的状態を指す。

アンドロゲン依存性症状には、にきび[1]脂漏症[2][3][4]男性型脱毛症[5]多毛症[6]汗腺炎[7]、男児の思春期早発症[8]性欲亢進症[9]性的倒錯[10]前立腺肥大症(BPH)[11]前立腺癌[12]、女性の多嚢胞性卵巣症候群(PCOS)[13][14]などの高アンドロゲン症などが知られている。

このような症状は、抗アンドロゲン作用を有する薬剤で治療する事が出来る。例えば、酢酸シプロテロンスピロノラクトンビカルタミドなどのアンドロゲン受容体拮抗薬英語版フィナステリドデュタステリドなどの5α-還元酵素阻害薬英語版、酢酸アビラテロンなどのCYP17A1阻害剤、リュープロレリンセトロレリクスなどの性腺刺激ホルモン放出ホルモン(GnRH)アナログ、酢酸メゲストロール酢酸メドロキシプロゲステロンなどの抗ゴナドトロピン薬英語版などがある[15][16]

関連項目編集

出典編集

  1. ^ Joseph E. Pizzorno; Michael T. Murray (2013). Textbook of Natural Medicine. Elsevier Health Sciences. pp. 1157–. ISBN 1-4377-2333-0. https://books.google.com/books?id=6cjgo1IixvEC&pg=PA1157 
  2. ^ Steven B. Hoath; Howard I. Maibach (18 April 2003). Neonatal Skin: Structure and Function. CRC Press. pp. 67–. ISBN 978-0-8247-0887-0. https://books.google.com/books?id=KNQ9mY7ZkwUC&pg=PA67 
  3. ^ Mariagrazia Stracquadanio; Lilliana Ciotta (20 April 2015). Metabolic Aspects of PCOS: Treatment With Insulin Sensitizers. Springer International Publishing. pp. 25–. ISBN 978-3-319-16760-2. https://books.google.com/books?id=w5xwCAAAQBAJ&pg=PA25 
  4. ^ Krishna; Usha R. (1 March 2000). Adolescence. Orient Blackswan. pp. 124–. ISBN 978-81-250-1794-3. https://books.google.com/books?id=wPQ6LVIQaQQC&pg=PA124 
  5. ^ Mark G. Lebwohl; Warren R. Heymann; John Berth-Jones; Ian Coulson (19 September 2013). Treatment of Skin Disease: Comprehensive Therapeutic Strategies. Elsevier Health Sciences UK. pp. 36–. ISBN 978-0-7020-5236-1. https://books.google.com/books?id=hRryAAAAQBAJ&pg=PA36 
  6. ^ Wilma F. Bergfeld (22 February 1996). A Woman Doctor's Guide to Skin Care: Essential Facts and Information on Keeping Skin Healthy. Hyperion. ISBN 978-0-7868-8100-0. https://books.google.com/books?id=zE9CjIgP7MYC 
  7. ^ Sarah Bekaert (2007). Women's Health: A Practical Guide for Healthcare Professionals. Radcliffe Publishing. pp. 128–. ISBN 978-1-84619-029-2. https://books.google.com/books?id=1tWoLXYw9wsC&pg=PA128 
  8. ^ Ora Hirsch Pescovitz; Erica A. Eugster (2004). Pediatric Endocrinology: Mechanisms, Manifestations, and Management. Lippincott Williams & Wilkins. pp. 328–. ISBN 978-0-7817-4059-3. https://books.google.com/books?id=9gvBlktAT6YC&pg=PA328 
  9. ^ Newsletter. The Academy. (1986). https://books.google.com/books?id=HJtGAQAAIAAJ 
  10. ^ Adrian Raine (2006). Crime and Schizophrenia: Causes and Cures. Nova Publishers. pp. 290–. ISBN 978-1-59454-609-9. https://books.google.com/books?id=3vy6kkygp9IC&pg=PA290 
  11. ^ Christopher R. Chapple; William D. Steers (10 May 2011). Practical Urology: Essential Principles and Practice: Essential Principles and Practice. Springer Science & Business Media. pp. 361–. ISBN 978-1-84882-034-0. https://books.google.com/books?id=A9m8TkdCUqEC&pg=PA361 
  12. ^ P. J. Bentley (1980). Endocrine Pharmacology: Physiological Basis and Therapeutic Applications. CUP Archive. pp. 321–. ISBN 978-0-521-22673-8. https://books.google.com/books?id=W6M9AAAAIAAJ&pg=PA321 
  13. ^ Raphael Rubin; David S. Strayer; Emanuel Rubin; Jay M. McDonald (2008). Rubin's Pathology: Clinicopathologic Foundations of Medicine. Lippincott Williams & Wilkins. pp. 816–. ISBN 978-0-7817-9516-6. https://books.google.com/books?id=kD9VZ267wDEC&pg=PA816 
  14. ^ Andrea Dunaif; R. Jeffrey Chang; Stephen Franks; Richard S. Legro (12 January 2008). Polycystic Ovary Syndrome: Current Controversies, from the Ovary to the Pancreas. Springer Science & Business Media. pp. 222–. ISBN 978-1-59745-108-6. https://books.google.com/books?id=xdxqJuE7tSwC&pg=PA222 
  15. ^ Kenneth L. Becker (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 1195–. ISBN 978-0-7817-1750-2. https://books.google.com/books?id=FVfzRvaucq8C&pg=PA1195 
  16. ^ Annual Reports in Medicinal Chemistry. Academic Press. (3 October 1994). pp. 1994–. ISBN 978-0-08-058373-0. https://books.google.com/books?id=e2koZ5uWeaYC&pg=PA1994 

関連書籍編集

  • Shukla, G. C.; Plaga, A. R.; Shankar, E.; Gupta, S. (2016). “Androgen receptor-related diseases: what do we know?”. Andrology 4: 366–381. doi:10.1111/andr.12167. ISSN 2047-2919.